MCAM (melanoma cell adhesion molecule)

Phorbol ester and cyclic AMP-mediated regulation of the melanoma-associated cell adhesion molecule MUC18/MCAM.

MUC18/MCAM is a melanoma-associated cell adhesion molecule that is also occasionally found on carcinomas and other tumor types. On melanomas, MUC18 expression increases with tumor progression and is found on more than 70% of metastatic lesions. To investigate the regulation of MUC18 expression, cell lines of diverse tissue origin were exposed to cytokines, regulators of intracellular cyclic AMP...

Receptor Lymphocyte and Is an Endothelial Adhesion Promotes Rolling via Microvilli Induction in Endothelium Interaction: MCAM/CD146 Molecule (MCAM)/CD146 in Lymphocyte Dual Role of Melanoma Cell Adhesion

Lymphocyte and Is an Endothelial Adhesion Promotes Rolling via Microvilli Induction in Endothelium Interaction: MCAM/CD146 Molecule (MCAM)/CD146 in Lymphocyte Dual Role of Melanoma Cell Adhesion

Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator mader in normal human CNS.

The proteins MUC18 and Mader have been identified as markers of tumor progression in melanoma cells. MUC18, also known as MCAM (melanoma cell adhesion molecule) and as CD146 (endothelial antigen), is a cell adhesion molecule belonging to the immunoglobulin superfamily. Mader is a transcriptional regulator shown to negatively regulate EGR-1. As it is known that neoplastic cells of neuroectoderma...

Expression of the Cell Adhesion Molecule CD146/MCAM in Non-Small Cell Lung Cancer

Expression of MCAM is observed in a variety of human malignancies. We aimed to determine the rate of MCAM expression in our non-small cell lung cancer (NSCLC) collection and to clarify its correlation with clinicopathological parameters and patient survival. 85 NSCLC were analysed immunohistochemically using a monoclonal MCAM antibody (clone N1238) on an NSCLC tissue micro array. The staining w...